News from the iDeAC Network

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First UK-wide study of brain complications in patients with COVID-19

First UK-wide study of brain complications in patients with COVID-19

Researchers from the University of Southampton are amongst a UK team of scientists to conduct the first nationwide surveillance study of the neurological complications of COVID-19.
A study of 153 patients treated in UK hospitals during the acute phase of the COVID-19 pandemic describes a range of neurological and psychiatric complications that may be linked to the disease, including stroke and an altered mental state such as brain inflammation, psychosis and dementia-like symptoms.

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New funding for study into Alzheimer’s disease

New funding for study into Alzheimer’s disease

Scientists at the University of Southampton have received nearly £100,000 from Alzheimer’s Research UK to investigate how fluid and toxic waste (amyloid) is removed from the brain.
Fluid and toxic waste is often removed from the brain through the walls of the brain’s arteries, a process called Intramural Periarterial Drainage (IPAD). However, when IPAD fails the fluid and toxic waste remains in the brain deposition of Aβ in these channels.

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Link between brain waste and Alzheimer’s

Link between brain waste and Alzheimer’s

New research from the University of Southampton has shed new light on the mechanisms of Alzheimer’s Disease.
One of the key features of Alzheimer’s is the build-up of toxic waste in the walls of arteries of the brain.
An interdisciplinary team of scientists from Medicine and Maths has demonstrated that the smooth muscle cells in cerebral arteries provide the motive force for the elimination of fluid and toxic waste (amyloid) from the brain. This force is called vasomotion. Vasomotion fails with increasing age and various metabolic risk factors leading to Alzheimer’s disease.

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Southampton researcher de-stigmatises dementia in powerful charity campaign

Southampton researcher de-stigmatises dementia in powerful charity campaign

University of Southampton researcher, Dr Jay Amin, has taken the spotlight in a new charity film exploring Dementia with Lewy bodies (DLB).
The film is part of Alzheimer’s Research UK and Ricoh’s joint campaign, Dementia Uncovered, which highlights the many physical diseases that cause dementia, as well as the scientists striving to bring about new dementia treatments.
Dr Amin’s research into DLB in Southampton focusses on inflammation, a process implicated in the progression of the disease.

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Alzheimer’s Disease Scientists identify critical window for treatment

Alzheimer’s Disease Scientists identify critical window for treatment

Researchers from the Southampton Neuroscience Group at the University of Southampton have made a significant development in understanding how Alzheimer’s disease spreads through the brain, discovering a significant period of time where medical intervention could halt its onset.
A hallmark of Alzheimer’s disease is the accumulation of tau protein in neurons which causes loss of brain volume. This build up, is known as neurofibrillary tangles, and formed when a diseased version of tau folds itself incorrectly. Prior to this significant research, recently published in The Journal of Neuroscience, very little was known about the timescale of this process and how the misfolded tau proteins spread to other cells.

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Microglia: Jekyll and Hyde in the brain

Microglia: Jekyll and Hyde in the brain

Delphine Boche, Professor of Neuroimmunopathology in the Faculty of Medicine, will deliver her Inaugural Lecture this month (October), in which she will talk about her research into brain inflammation and degeneration and her journey to academia. Here, she talks about her research interests and aspirations.
What is your current research focus?
The immune cells of the brain, microglia, in different neurological conditions

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