Theme: Clinical Trials and Therapeutics

There is a long history of dementia, brain ageing and neurodegenerative disease trials in Southampton. The Memory Assessment and Research Centre (Moorgreen Hospital, Southern Health FT) has a strong track record of delivery in dementia trials and participated in the earliest trials of cognitive enhancing medication for dementia. At Southampton, the Neurosciences Research Group conducts Phase 2 and Phase 3 trials through the University Hospital Southampton NIHR CRF facility for a range of dementias.

IDeAC members from this theme are currently involved in over 30 clinical trials in dementia and neurological conditions active at Southampton sites, including international trials of cutting edge investigational therapeutic compounds.

The nature of clinical trials fosters external collaboration, and regional, national and international links are already established. The Clinical Research Network provides strong support for clinical trials infrastructure in the region, and a regional network of memory clinics supports recruitment to trials. The theme bridges other themes with strong links to the Clinical Diagnosis and Prognosis theme, the Community and Post-Diagnostic Care theme and the NIHR Applied Research Collaboration (NIHR ARC).

Dr Boyd Ghosh

Clinical Trials

Dr Christopher Kipps

Clinical Research lead

Dr Jay Amin

Clinical Trials

Dr Roxana Carare

Vascular

Using electronic patient records to examine patient outcomes in Dementia with Lewy bodies

Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia. However, people with DLB often experience missed or delayed diagnosis. The Clinical Record Interactive Search (CRIS) system allows research and service …

Combining Memantine and Cholinesterase inhibitors in Lewy body dementia treatment trial (COBALT)

Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) are two neurodegenerative cause of dementia, in which patients are generally treated with Cholinesterase inhibitors. This is an NIHR Health Technology Assessment funded international multi-centre …

Phase 1 trial of bepranemab in progressive supranuclear palsy

Phase 1 trial of bepranemab in progressive supranuclear palsy

Use of antisense oligonucleotide in Progressive supranuclear palsy

Phase 1 first in human clinical trial in patients with progressive supranuclear palsy.

Treating impulsivity in people with progressive supranuclear palsy

Phase 2/3 clinical trial investigating the use of Atomoxetine to treat impulsivity