Basic and Translational Science
Harnessing the heart-lung-brain interactions in the search for vascular biomarkers for neurological dysfunction

 Theme Group:


About the project:

As an interdisciplinary team from University Hospital Southampton & University of Southampton comprising specialists in cardiothoracic surgery, ophthalmology, cardiac perfusion, imaging, mathematics and neuroanatomy we are in the optimal position to conduct a study in order to investigate the heart-lung-brain interactions and their effect on the variability of cerebral blood flow in anaesthetised patients undergoing cardiothoracic surgery with cardiopulmonary bypass and different levels of hypothermia. By systematically and methodically being able to control elements of the cardiovascular and respiratory systems function we can isolate the different signals transmitted from the brain blood flow and prove that spontaneous cerebral vasomotion as a key motive force for the clearance of fluid from the brain is present and is initiated in the wall of the cerebral arteries.


Mr Aiman Alzetani D (Southampton General Hospital), Professor Roxana Carare (University of Southampton),  Professor Parwez Hossain (Southampton General Hospital), Professor Giles Richardson (University of Southampton), Dr Tony Birch (Southampton General Hospital) and  Professor David Simpson (University of Southampton).

Key iDeAC expertise:

Dr Roxana Carare


Dr Tony Birch

Imaging (human)

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