As an interdisciplinary team from University Hospital Southampton & University of Southampton comprising specialists in cardiothoracic surgery, ophthalmology, cardiac perfusion, imaging, mathematics and neuroanatomy we are in the optimal position to conduct a study in order to investigate the heart-lung-brain interactions and their effect on the variability of cerebral blood flow in anaesthetised patients undergoing cardiothoracic surgery with cardiopulmonary bypass and different levels of hypothermia. By systematically and methodically being able to control elements of the cardiovascular and respiratory systems function we can isolate the different signals transmitted from the brain blood flow and prove that spontaneous cerebral vasomotion as a key motive force for the clearance of fluid from the brain is present and is initiated in the wall of the cerebral arteries.
Understanding the dynamics and diversity of microglia in health and disease
Our lab is focused to studying the population of microglial cells from development to ageing, as well as chronic neurodegenerative disease such as Alzheimer’s. We have ongoing projects studying both rodent and human microglia, characterising …
Adrenergic interventions for novel treatment strategies in Alzheimer’s disease
Computational modelling shows that innervation of vascular smooth muscle cells provides the motive force for IPAD, which has led us to hypothesize that 1) failure of elimination of Aβ along IPAD pathways could be a …