Research projects

Clinical Trials and Therapeutics
Using electronic patient records to examine patient outcomes in Dementia with Lewy bodies

 Theme Group:

About the project:

Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia. However, people with DLB often experience missed or delayed diagnosis. The Clinical Record Interactive Search (CRIS) system allows research and service improvement work to take place that has previously not been possible, by allowing access to deidentified patient records. In this project we will use CRIS to explore patient outcomes in Dementia with Lewy bodies within Southern Health NHS Foundation Trust, including duration of disease, mortality and rates of hospital admission. We will also explore early clinical features using Natural Language Processing, in collaboration with other UK centres.

Dr Jay Amin
Key theme lead:

Related projects:

Combining Memantine and Cholinesterase inhibitors in Lewy body dementia treatment trial (COBALT)

Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) are two neurodegenerative cause of dementia, in which patients are generally treated with Cholinesterase inhibitors. This is an NIHR Health Technology Assessment funded international multi-centre …

Phase 1 trial of bepranemab in progressive supranuclear palsy

Phase 1 trial of bepranemab in progressive supranuclear palsy

Use of antisense oligonucleotide in Progressive supranuclear palsy

Phase 1 first in human clinical trial in patients with progressive supranuclear palsy.

Treating impulsivity in people with progressive supranuclear palsy

Phase 2/3 clinical trial investigating the use of Atomoxetine to treat impulsivity