Research projects

Basic and Translational Science
Understanding the dynamics and diversity of microglia in health and disease

Dr Diego Gomez-Nicola’s lab is focused on studying the population of microglial cells from development to ageing, as well as chronic neurodegenerative disease’s such as Alzheimer’s Disease. The lab has several ongoing projects studying both rodent and human microglia, characterising it’s dynamics and phenotype with a range of techniques such as molecular phenotyping, scRNAseq, as well as modulating their activity via pharmacological or transgenic interventions. They are particularly interested in the role of proliferation and senescence in the specification of detrimental microglial phenotypes that can be targeted as a therapeutic approach in Dementia.

Dr Diego Gomez-Nicola

Related projects:

Adrenergic interventions for novel treatment strategies in Alzheimer’s disease

Computational modelling shows that innervation of vascular smooth muscle cells provides the motive force for IPAD, which has led us to hypothesize that 1) failure of elimination of Aβ along IPAD pathways could be a …

Harnessing the heart-lung-brain interactions in the search for vascular biomarkers for neurological dysfunction

As an interdisciplinary team from University Hospital Southampton & University of Southampton comprising specialists in cardiothoracic surgery, ophthalmology, cardiac perfusion, imaging, mathematics and neuroanatomy we are in the optimal position to conduct a study in …