Dr Amritpal Mudher is a Professor of Neurosciences within Biological Sciences at the University of Southampton. The overarching aim of her research is to investigate the mechanisms that underpin tau-mediated dysfunction and degeneration in tauopathies such as Alzheimer’s disease and fronto-temporal dementia (see Mudher et al 2004, Mol Psychiatry, Chee et al 2005 for early investigations). This work led her team to identify disease-modifying tau-centred therapeutic targets (See Quriase et al 2013 Mol. Psychiatry). It has also raised interesting questions about the pathological significance of established tau aggregates such as soluble forms of tau, tau oligomers and tau filaments. More recently she is assessing whether tau-mediated axonal degeneration is wallerian in nature.
