Research Projects

– Basic and Translational Science

Understanding the dynamics and diversity of microglia in health and disease

Dr Diego Gomez-Nicola’s lab is focused on studying the population of microglial cells from development to ageing, as well as chronic neurodegenerative disease’s such as Alzheimer’s Disease. The lab has several ongoing projects studying both rodent and human microglia, characterising it’s dynamics and phenotype with a range of techniques such as molecular phenotyping, scRNAseq, as well as modulating their activity via pharmacological or transgenic interventions. They are particularly interested in the role of proliferation and senescence in the specification of detrimental microglial phenotypes that can be targeted as a therapeutic approach in Dementia.

Principal Investigator: Dr Diego Gomez-Nicola

Contact: Dr Diego Gomez-Nicola – d.gomez-nicola@soton.ac.uk