Clinical Academic Training Posts
Alzheimer’s disease (AD), Lewy Body Dementia (DLB) and Parkinson’s Disease (PD) have complex aetiology and pathogenesis and predicting the rate of clinical progression remains challenging. In Southampton, we showed that systemic inflammation increases the risk for earlier onset and/or progression of AD. In this project we will perform an in-depth analysis of serum and CSF samples to link pathways of inflammation to clinical progression. We will also measure amyloid, tau and alpha-synuclein and use state-of-the-art biophysical technology to link inflammation to specific conformers Collectively, this work may lead to novel composite biomarker to allow better diagnosis and allow better prediction of cognitive decline.