Inflammation is the body’s normal response to injury and infection. It can be healthy or harmful depending on the situation. We know that when people with dementia get infections their memory symptoms can get worse. …
Research projects
Diagnostic biomarkers of gut microbiome-associated phenotypes predictive of healthy aging and neurodegenerative disease (BIO-AGE)
The gastrointestinal tract in humans is one of the largest interfaces between the host and the environment. Different bacteria in the gut have been linked with longevity and healthy ageing. However, some of these bacteria …
BRAIN AI: Biomarker Research Assessing Inflammation in Neurodegeneration using Artificial Intelligence
Dementia diagnosis is complex and subjective, especially in the early stages of the disease. It takes on average over 2 years from symptom onset to diagnosis. Inflammation is seen as a driver leading to accelerated …
Measuring the control of blood flow to the brain
It goes without saying that blood flow to the brain is essential for life. The simplistic view of the blood vessels as a fixed set of pipes, like the plumbing system in a house, helps …
Investigating Quality of Care for People with Dementia Undergoing Cancer Treatment in Ambulatory Care (IMPACT)
Little information exists concerning the implications of comorbid cancer-dementia for people having cancer treatment, particularly in an ambulatory care setting. However, it is known that people with dementia have poorer cancer outcomes than those without …
Dementia and Incontinence at Home (DINAH)
This 4-year mixed methods study is focused on better understanding the problems faced by people (and their family carers) living at home with dementia and incontinence. The first phase of the study comprised 45 semi-structured …
Treating impulsivity in people with progressive supranuclear palsy
Phase 2/3 clinical trial investigating the use of Atomoxetine to treat impulsivity
Use of antisense oligonucleotide in Progressive supranuclear palsy
Phase 1 first in human clinical trial in patients with progressive supranuclear palsy.
Phase 1 trial of bepranemab in progressive supranuclear palsy
Phase 1 trial of bepranemab in progressive supranuclear palsy
INVOLVing pEople with cognitive impaiRment in decisions about their hospital nursing care (INVOLVER): a pilot study
We want to help nurses look after their patients in hospital. We want to help them find out how each patient likes to do things like getting clean, going to the toilet, eating and drinking. …