Clinical Academic Training Posts
Basic and Translational Science
CSF dynamics in cognitively impaired patients
An association exists between intracranial pulsing and cognitive decline. This is seen in blood and CSF flow. Increased arterial stiffness is a possible mechanism; measures of pressure pulsing would help to confirm this. While flow measurements can be made relatively easily, intracranial pressure measurements are challenging. We have developed a novel approach measuring pulsations of the tympanic membrane and shown this to be associated with the MOCA cognitive assessment test in healthy subjects. There would be good support for a clinical academic trainee to explore these measurements of CSF dynamics in cognitively impaired patients.