Dr Tracey Newman is Associate Professor in Clinical Neurosciences within Medicine at the University of Southampton. She leads a multidisciplinary group that investigates immune mediated mechanisms that lead to neuronal injury, and its consequences, in the central nervous system. Members of the group are developing the use of biocompatible nanoparticle delivery and reporter systems.
– Basic and Translational Science
Roxana Carare is a medically qualified Professor of Clinical Neuroanatomy and experimental neuropathology in the University of Southampton. Having graduated in general medicine in 1994 in Bucharest, Roxana completed her PhD in experimental neuropathology in 2006, in the University of Southampton, UK. The main international recognition for Roxana Carare has come from the neuroanatomy and neuropathology interdisciplinary research she leads, demonstrating the unique lymphatic drainage pathways by which fluid and soluble amyloid are eliminated from the brain along basement membranes within the walls of cerebral capillaries and arteries (Intramural Periarterial Drainage Pathways, IPAD).
Jessica Teeling is a professor in Experimental Neuroimmunology within Biological Sciences at the University of Southampton. Her research focuses on understanding the immune regulatory pathways in the healthy, diseased and ageing central nervous system (CNS). Her group studies the effect of antibody mediated inflammation in the CNS, and how these responses may contribute to the pathogenesis of neuroinflammatory and neurodegenerative diseases, such as Alzheimer’s disease, age related macular degeneration and systemic lupus erythematosis. She is particularly interested in the role of Fcgamma receptors and microglial activation.
Dr Amritpal Mudher is a Associate Professor in Neurosciences within Biological Sciences at the University of Southampton. The overarching aim of her research is to investigate the mechanisms that underpin tau-mediated dysfunction and degeneration in tauopathies such as Alzheimer’s disease and fronto-temporal dementia (see Mudher et al 2004, Mol Psychiatry, Chee et al 2005 for early investigations). This work led her team to identify disease-modifying tau-centred therapeutic targets (See Quriase et al 2013 Mol. Psychiatry). It has also raised interesting questions about the pathological significance of established tau aggregates such as soluble forms of tau, tau oligomers and tau filaments. More recently she is assessing whether tau-mediated axonal degeneration is wallerian in nature.
Sumeet Mahajan is a Professor in Molecular Biophotonics & Imaging in Chemistry with a joint appointment in the Institute for Life Sciences at the University of Southampton. His group works at the life science interface. The overarching aim of the research in his group is to develop new spectroscopy and imaging techniques and apply them to extract chemical information from biological systems to understand disease processes for early, faster or more sensitive healthcare diagnostics.