Clinical Academic Training Posts

– Diagnosis and Prognosis

Blood-brain barrier integrity in dementia

Blood-brain barrier integrity in dementia

Several studies suggest that blood-brain barrier integrity is impaired in Alzheimer’s dementia. In this project it is hypothesized that dynamic contrast enhanced magnetic resonance imaging can be used to demonstrate this phenomenon, comparing Alzheimer’s dementia, Lewy body dementia and control individuals. The relationship of blood-brain barrier permeability to systemic inflammatory status as measured by urinary neopterin-to-creatinine ratio and blood cytokine assays is being investigated. Patients are being followed up to determine whether a baseline MRI assessment of blood-brain barrier integrity is predictive of future cognitive decline. The Academic Clinical Fellow working on the project may come from Psychiatry or Neurology backgrounds.

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